F-substituted carbonate apatite for promoting bone formation

Yu Sogo, Daiki Yokoyama, Atsuo Ito, Atsushi Yamazaki, Racquel Z. LeGeros

研究成果: Article査読


Fluoride (F)-substituted type-B carbonate-containing hydroxyapatites (CHAPs) were prepared as bone substitutes with a F-releasing ability. The F - contents in the F-substituted CHAPs were 16-22 times larger than that in normal adult human bones. The carbonate contents in the F-substituted CHAPs corresponded to that in human bones. The F-substituted CHAPs released F- in an acetic acid - sodium acetate buffer at pH 4.9; within only 3 h, the F- concentration in the buffer increased to more than 63.9 μg L-1, which was 1.5- 8.9 times higher than that in a body fluid of normal adult humans. Although the F- concentration rapidly decreased probably due to the precipitation of a certain phase containing F-, the F-substituted CHAPs exhibited the ability to increase the F- concentration in a body fluid by bone resorption. Therefore, it is expected that the F-substituted CHAPs will be feasible as a F-releasing material for promoting bone formation.

ジャーナルKey Engineering Materials
309-311 I
出版ステータスPublished - 2006 1 1

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学


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