Fabrication of genetic diagnostic chip using DNA-arrayed TFT photosensor

Keiichi Hatakeyama, Tsuyoshi Tanaka, Masahiro Sawaguchi, Akihito Iwadate, Yasushi Mizutani, Kazuhiro Sasaki, Naofumi Tateishi, Tadashi Matsunaga*

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

This work describes a disposable DNA-arrayed thin film transistor (TFT) photosensor integrating a miniaturized reaction unit and a photoelectronic effect-based internal detection sensor. Single stranded DNA was chemically conjugated and arrayed on the TFT photosensor, which was fabricated by the semiconductor integrated circuit (IC) technology, for the detection of specific target DNA by DNA-DNA hybridization. The photosensor surface can be modified by various silane coupling reagents for the optimization of oligonucleotide immobilization conditions and single nucleotide polymorphism (SNP) detection was successfully employed using the TFT photosensor. A microfluidic channels were constructed on the TFT photosensor to improve the hybridization efficiency. The developed TFT photosensor will further promote the development of disposable photodetecting devices applicable in genetic diagnosis.

本文言語English
ページ(範囲)573-575
ページ数3
ジャーナルElectrochemistry
76
8
出版ステータスPublished - 2008 8月
外部発表はい

ASJC Scopus subject areas

  • 電気化学

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