Fabrication of micropatterned fish scale collagen scaffold using soft lithography for oral mucosa tissue engineering

Kazuma Kishimoto, Keito Miwa, Ayako Suzuki, Isamu Yamaguchi, Yoshihiro Kodama, Orakarn Suebsamarn, Shuichi Shoji, Kenji Izumi, Jun Mizuno

研究成果: Conference contribution

抄録

Fish-derived collagen is considered a promising material for oral mucosa tissue engineering because it is free from risk of transmissible infectious diseases. We developed a novel fish scale collagen scaffold with micropatterns on which oral keratinocytes are cultured to create a tissue-engineered oral mucosa. Anisotropic and isotropic etching were used to fabricate negative patterns on the Si substrate and soft lithography was used to translate the patterns to PDMS and fish scale collagen. The histological evaluation of the tissue-engineered oral mucosa confirmed the successful formation of the epithelial layer mimicking oral mucosa in vivo. This study suggests that our novel approach for fabricating biomimetic scaffold is promising and will make a huge contribution to the field of oral mucosa regeneration.

本文言語English
ホスト出版物のタイトル2021 International Conference on Electronics Packaging, ICEP 2021
出版社Institute of Electrical and Electronics Engineers Inc.
ページ25-26
ページ数2
ISBN(電子版)9784991191114
DOI
出版ステータスPublished - 2021 5 12
イベント20th International Conference on Electronics Packaging, ICEP 2021 - Tokyo, Japan
継続期間: 2021 5 122021 5 14

出版物シリーズ

名前2021 International Conference on Electronics Packaging, ICEP 2021

Conference

Conference20th International Conference on Electronics Packaging, ICEP 2021
国/地域Japan
CityTokyo
Period21/5/1221/5/14

ASJC Scopus subject areas

  • 電子工学および電気工学
  • 材料力学
  • 電子材料、光学材料、および磁性材料
  • 器械工学

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