抄録
(-)-Ascochlorin was synthesized using palladium-catalyzed three component coupling reaction. Reaction of the aryl iodide 3, isoprene, and sodium p-toluenesulfinate in the presence of Pd2(dba)3CHCl 3 catalyst and NaHCO3 gave the 4-aryl-2-methyl-2- butenylsulfone 5 selectively in 68% yield. The allylic sulfone 5 was converted into the useful intermediate 2 in 5 steps, which was subjected to Julia olefination with the aldehyde 4 and deprotection gave (-)-ascochlorin.
本文言語 | English |
---|---|
ページ(範囲) | 654-655 |
ページ数 | 2 |
ジャーナル | Chemistry Letters |
巻 | 36 |
号 | 5 |
DOI | |
出版ステータス | Published - 2007 5 5 |
ASJC Scopus subject areas
- Chemistry(all)