Facile synthesis of (-)-ascochlorin using palladium-catalyzed three component coupling reaction

Makoto Aoki, Kenji Kawashima, Hirohisa Fujihara, Isao Shimizu*

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

(-)-Ascochlorin was synthesized using palladium-catalyzed three component coupling reaction. Reaction of the aryl iodide 3, isoprene, and sodium p-toluenesulfinate in the presence of Pd2(dba)3CHCl 3 catalyst and NaHCO3 gave the 4-aryl-2-methyl-2- butenylsulfone 5 selectively in 68% yield. The allylic sulfone 5 was converted into the useful intermediate 2 in 5 steps, which was subjected to Julia olefination with the aldehyde 4 and deprotection gave (-)-ascochlorin.

本文言語English
ページ(範囲)654-655
ページ数2
ジャーナルChemistry Letters
36
5
DOI
出版ステータスPublished - 2007 5 5

ASJC Scopus subject areas

  • 化学 (全般)

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