Facilitatory effects of somatostatin on reduced uptake of 2-deoxyglucose in cerebral cortical and hippocampal slices from aged rats

Shibata Shigenobu Shibata, Tanaka Takeshi Tanaka, Watanabe Shigenori Watanabe

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The aim of the present study was to determine whether or not the reduction of 2-deoxyglucose uptake by the cerebral cortical slices in aged rats (22-23 months old) was attenuated by somatostatin or carbachol. In 8-week-old rats, somatostatin and carbachol produced concentration-dependent increases in 2-deoxyglucose uptake. 2-Deoxyglucose uptake of the cortical slices in 2-23-month-old rats was significantly facilitated by treatment with 0.1-1 ωM somatostatin or 1-100 ωM carbachol. Metabolic responses to somatostatin or carbachol were quite similar in young and aged rats. The present results demonstrated that 2-deoxyglucose uptake by the cerebral cortex was facilitated by somatostatin and carbachol in both young and old rats.

本文言語English
ページ(範囲)269-272
ページ数4
ジャーナルEuropean Journal of Pharmacology: Molecular Pharmacology
269
2
DOI
出版ステータスPublished - 1994 10 14
外部発表はい

ASJC Scopus subject areas

  • Pharmacology

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