Features of behavioral changes underlying conditioned taste aversion in the pond snail Lymnaea stagnalis

Junko Nakai, Yuki Totani, Satoshi Kojima, Manabu Sakakibara, Etsuro Ito

研究成果査読

4 被引用数 (Scopus)

抄録

Conditioned taste aversion (CTA) in the freshwater pulmonate Lymnaea stagnalis can be formed by presenting ten pairings of sucrose as the conditioned stimulus (CS) and KCl as the unconditioned stimulus (US). The CTA is consolidated to long-term memory (LTM) lasting longer than a month. In the present study, we examined the time course of protein synthesis-dependent period during the consolidation of Lymnaea CTA to LTM by pharmacological inhibition of transcription or translation. The robustness for CTA–LTM was then examined by extinction trials, i.e., repeated presentations of the CS alone. Furthermore, we evaluated the effects of the interstimulus interval (ISI) between the presentation of the CS and US. Our findings indicated that the protein synthesis-dependent period coincides with the CTA training. Repeated presentations of the CS alone after establishment of CTA did not extinguish the CTA, demonstrating the robustness of the CTA–LTM. The ISI ranged from 10 s to a few minutes, and there was no inverted U-shaped function between the ISI and the conditioned response (i.e., suppression of feeding). Thus, CTA still formed even when the presentation of the US was delayed. These features of Lymnaea CTA complement the knowledge for mammalian CTA.

本文言語English
論文番号8
ジャーナルInvertebrate Neuroscience
20
2
DOI
出版ステータスPublished - 2020 6 1

ASJC Scopus subject areas

  • 発達神経科学
  • 細胞および分子神経科学

フィンガープリント

「Features of behavioral changes underlying conditioned taste aversion in the pond snail Lymnaea stagnalis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル