FGF-2/calcium phosphate composite layer to resist bacterial infection

Y. Sogo*, A. Ito, H. Mutsuzaki, A. Oyane, M. Onoguchi, N. Ichinose, M. Sakane, N. Ochiai

*この研究の対応する著者

研究成果: Article査読

1 被引用数 (Scopus)

抄録

A FGF-2-apatite composite layer (FGF-AP layer) was formed on the surface of Ti screws in a supersaturated calcium phosphate solution supplemented with FGF-2. By an in vitro study using fibroblastic NIH3T3 cells, it was confirmed that FGF-2 was immobilized in the layer without complete denaturation although the composite layer was formed at 37°C. When Ti screws with the FGF-AP layer were percutaneously implanted in the proximal tibial metaphysis of 16 rabbits, no osteomyelitis was observed in any rabbits although a FGF-2-free AP layer allowed osteomyelitis in some cases in our previous study. These results suggest that a FGF-AP layer formed on Ti screws is useful for resisting bacterial infection during external fixations.

本文言語English
ページ(範囲)691-694
ページ数4
ジャーナルKey Engineering Materials
330-332 I
DOI
出版ステータスPublished - 2007

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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