Fifty-second analysis of oxidative stress markers in human plasma using amide-modified liquid chromatography chip

M. Isokawa, K. Nakanishi, Donghyun Yoon, Tetsushi Sekiguchi, T. Funatsu, Shuichi Shoji, M. Tsunoda

研究成果: Conference contribution

抜粋

This paper reports 50-s liquid chromatography (LC) separation of oxidative stress markers using an amide-modified pillar array column (PAC). The amide modification enables a sufficient retention of highly polar compounds under hydrophilic interaction LC (HILIC) conditions, and five fluorescence-labeled biothiols, i.e., cysteine, homocysteine, glutathione, cysteinylglycine, and N-acetylcysteine, in human plasma could be rapidly separated. Since these biothiols are associated with many diseases, this newly developed method could be a useful tool for the diagnosis or clinical investigation of biothiol-related diseases.

元の言語English
ホスト出版物のタイトル20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
出版者Chemical and Biological Microsystems Society
ページ583-584
ページ数2
ISBN(電子版)9780979806490
出版物ステータスPublished - 2016
イベント20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
継続期間: 2016 10 92016 10 13

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Ireland
Dublin
期間16/10/916/10/13

    フィンガープリント

ASJC Scopus subject areas

  • Control and Systems Engineering

これを引用

Isokawa, M., Nakanishi, K., Yoon, D., Sekiguchi, T., Funatsu, T., Shoji, S., & Tsunoda, M. (2016). Fifty-second analysis of oxidative stress markers in human plasma using amide-modified liquid chromatography chip. : 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 583-584). Chemical and Biological Microsystems Society.