抜粋
(Equation presented) The first total synthesis of (+)-phomopsidin has been achieved via a diastereoselective transannular Diels-Alder (TADA) reaction. Key steps in the synthesis include diastereoselective ynone reduction with (-)-α-pinene and 9-BBN, macrocyclization by E-selective intramolecular Horner-Wadsworth-Emmons (HWE) reaction, as well as carbometalation under Wipf's conditions, followed by HWE reaction at low temperature to selectively construct the (E)-1-methylpropenyl and (1E,2E)-4-carboxy-1,3-butadienyl substituents.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 553-556 |
| ページ数 | 4 |
| ジャーナル | Organic Letters |
| 巻 | 6 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | Published - 2004 2 19 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
フィンガープリント First Total Synthesis of Antimitotic Compound, (+)-Phomopsidin' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Suzuki, T., Usui, K., Miyake, Y., Namikoshi, M., & Nakada, M. (2004). First Total Synthesis of Antimitotic Compound, (+)-Phomopsidin. Organic Letters, 6(4), 553-556. https://doi.org/10.1021/ol036338q