Flunitrazepam effects on human sleep EEG spectra II: Sigma and beta alterations during NREM sleep

Sunao Uchida*, Nobuyuki Okudaira, Kyoko Nishihara, Yoshinobu Iguchi, Xin Tan

*この研究の対応する著者

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Flunitrazepam (FNZ) is known to enhance the higher EEG frequencies, including sigma (10-15 Hz) and beta (20-28 Hz). Both sigma and beta frequency bands show an inverse relationship with delta (0.3-3 Hz) during NREM periods, as we have previously reported. It is not known whether generation of these two EEG frequencies is mediated by the same or different neuronal mechanisms. In this report, we compare alterations of delta, sigma and beta EEG induced by FNZ (4 mg) orally administered to five healthy male subjects for seven consecutive nights. Sleep EEG on the baseline night (BLN), and the fourth and seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. On drug nights, sigma was enhanced without regard to delta amount, but beta was enhanced only during epochs containing low delta. Thus, sigma and beta EEG were altered differently by the same pharmacological agent. These results suggest that sigma and beta EEG are mediated by different neuronal mechanisms.

本文言語English
ジャーナルLife Sciences
59
9
出版ステータスPublished - 1996 7月 26
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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