Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT 2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors

Katsunori Nonogaki, Kana Nozue, Yukiko Takahashi, Nobuyuki Yamashita, Shuichi Hiraoka, Hiroaki Kumano, Tomifusa Kuboki, Yohsitomo Oka

研究成果: Article

28 引用 (Scopus)

抜粋

Serotonin (5-hydroxytryptamine; 5-HT) 2C receptors and the downstream melanocortin pathway are suggested to mediate the appetite-suppressing effects of 5-HT drugs such as m-chlorophenylpiperazine (mCPP) and fenfluramine. Here, we report that fluvoxamine (3-30 mg/kg), a selective serotonin reuptake inhibitor (SSRI), in the presence of SB 242084 (1-2 mg/kg), a selective 5-HT2C receptor antagonist, exerts appetite-suppressing effects while fluvoxamine or SB 242084 alone has no effect. The appetite-suppressing effects were attenuated in the presence of SB 224289 (5 mg/kg), a selective 5-HT1B receptor antagonist. Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression. These results suggest that fluvoxamine and inactivation of 5-HT2C receptors exert feeding suppression through activation of 5-HT1B receptors, and that 5-HT1C receptors up-regulate hypothalamic POMC and CART gene expression and down-regulate hypothalamic orexin gene expression in mice.

元の言語English
ページ(範囲)675-681
ページ数7
ジャーナルInternational Journal of Neuropsychopharmacology
10
発行部数5
DOI
出版物ステータスPublished - 2007 10 9

    フィンガープリント

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

これを引用