Formation of magnetite by bacteria and its application

Atsushi Arakaki, Hidekazu Nakazawa, Michiko Nemoto, Tetsushi Mori, Tadashi Matsunaga*

*この研究の対応する著者

研究成果査読

174 被引用数 (Scopus)

抄録

Magnetic particles offer high technological potential since they can be conveniently collected with an external magnetic field. Magnetotactic bacteria synthesize bacterial magnetic particles (BacMPs) with well-controlled size and morphology. BacMPs are individually covered with thin organic membrane, which confers high and even dispersion in aqueous solutions compared with artificial magnetites, making them ideal biotechnological materials. Recent molecular studies including genome sequence, mutagenesis, gene expression and proteome analyses indicated a number of genes and proteins which play important roles for BacMP biomineralization. Some of the genes and proteins identified from these studies have allowed us to express functional proteins efficiently onto BacMPs, through genetic engineering, permitting the preservation of the protein activity, leading to a simple preparation of functional protein-magnetic particle complexes. They were applicable to high-sensitivity immunoassay, drug screening and cell separation. Furthermore, fully automated single nucleotide polymorphism discrimination and DNA recovery systems have been developed to use these functionalized BacMPs. The nano-sized fine magnetic particles offer vast potential in new nano-techniques.

本文言語English
ページ(範囲)977-999
ページ数23
ジャーナルJournal of the Royal Society Interface
5
26
DOI
出版ステータスPublished - 2008 9 6
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • バイオテクノロジー
  • バイオエンジニアリング
  • 生体医工学
  • 生体材料
  • 生化学

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