Four aromatic sulfates with an inhibitory effect against HCV NS3 helicase from the crinoid alloeocomatella polycladia

Idam Hermawan, Atsushi Furuta, Masahiro Higashi, Yoshihisa Fujita, Nobuyoshi Akimitsu, Atsuya Yamashita, Kohji Moriishi, Satoshi Tsuneda, Hidenori Tani, Masamichi Nakakoshi, Masayoshi Tsubuki, Yuji Sekiguchi, Naohiro Noda*, Junichi Tanaka

*この研究の対応する著者

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Bioassay-guided separation of a lipophilic extract of the crinoid Alloeocomatella polycladia, inhibiting the activity of HCV NS3 helicase, yielded two groups of molecules: cholesterol sulfate and four new aromatic sulfates 1-4. The structures of the aromatics were elucidated by spectroscopic analysis in addition to theoretical studies. The aromatic sulfates 1-4 showed moderate inhibition against NS3 helicase with IC50 values of 71, 95, 7, and 5 μM, respectively.

本文言語English
論文番号117
ジャーナルMarine Drugs
15
4
DOI
出版ステータスPublished - 2017 4月

ASJC Scopus subject areas

  • 創薬

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