Foxg1 Suppresses Early Cortical Cell Fate

Carina Hanashima, Suzanne C. Li, Lijian Shen, Eseng Lai*, Gord Fishell

*この研究の対応する著者

研究成果: Article査読

281 被引用数 (Scopus)

抄録

During mammalian cerebral corticogenesis, progenitor cells become progressively restricted in the types of neurons they can produce. The molecular mechanism that determines earlier versus later born neuron fate is unknown. We demonstrate here that the generation of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1. In Foxg1 null mutants, we observed an excess of Cajal-Retzius neuron production in the cortex. By conditionally inactivating Foxg1 in cortical progenitors that normally produce deep-layer cortical neurons, we demonstrate that Foxg1 is constitutively required to suppress Cajal-Retzius cell fate. Hence, the competence to generate the earliest born neurons during later cortical development is actively suppressed but not lost.

本文言語English
ページ(範囲)56-59
ページ数4
ジャーナルScience
303
5654
DOI
出版ステータスPublished - 2004 1 2
外部発表はい

ASJC Scopus subject areas

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