Foxp3+ T Cells Regulate Immunoglobulin A Selection and Facilitate Diversification of Bacterial Species Responsible for Immune Homeostasis

Shimpei Kawamoto, Mikako Maruya, LuciaM Kato, Wataru Suda, Koji Atarashi, Yasuko Doi, Yumi Tsutsui, Hongyan Qin, Kenya Honda, Takaharu Okada, Masahira Hattori, Sidonia Fagarasan*

*この研究の対応する著者

研究成果: Article査読

280 被引用数 (Scopus)

抄録

Foxp3+ Tcells play a critical role for the maintenance of immune tolerance. Here we show that in mice, Foxp3+ Tcells contributed to diversification of gut microbiota, particularly of species belonging to Firmicutes. The control of indigenous bacteria by Foxp3+ Tcells involved regulatory functions both outside and inside germinal centers (GCs), consisting of suppression of inflammation and regulation of immunoglobulin A (IgA) selection in Peyer's patches, respectively. Diversified and selected IgAs contributed to maintenance of diversified and balanced microbiota, which in turn facilitated the expansion of Foxp3+ Tcells, induction of GCs, andIgA responses in the gut through a symbiotic regulatory loop. Thus,the adaptive immune system, through cellular and molecular components that arerequired for immune tolerance and through the diversification as well as selection of antibody repertoire, mediates host-microbial symbiosis by controlling the richness and balance of bacterial communities required for homeostasis.

本文言語English
ページ(範囲)152-165
ページ数14
ジャーナルImmunity
41
1
DOI
出版ステータスPublished - 2014 7 17
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 感染症
  • 免疫学

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