Fraction estimation of small, dense LDL using autocorrelation function of dynamic light scattering

Suchin Trirongjitmoah, Toshihiro Sakurai, Kazuya Iinaga, Hitoshi Chiba, Koichi Shimizu

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Small, dense low-density lipoprotein (sdLDL) in total LDL is strongly related with the cardiovascular risk level, An optical technique using dynamic light scattering (DLS) measurement is useful for point-ofcare testing of sdLDL. However, the sdLDL fraction estimated from the particle size distribution in DLS data is sensitive to noise and artifacts. Therefore, we derived analytical solutions in a closed form to estimate the fraction of scatterers using the autocorrelation function of scattered light from a polydisperse solution. The effect of the undesired large particles can be eliminated by the pre-processing of the autocorrelation function. The proposed technique was verified using latex standard particles and LDL solutions. Results suggest the feasibility of this technique to estimate the sdLDL fraction using optical scattering measurements

本文言語English
ページ(範囲)6315-6326
ページ数12
ジャーナルOptics Express
18
6
DOI
出版ステータスPublished - 2010 3 15
外部発表はい

ASJC Scopus subject areas

  • 原子分子物理学および光学

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