From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis-specific recombinase Dmc1

Wataru Kagawa*, Hitoshi Kurumizaka

*この研究の対応する著者

    研究成果: Article査読

    31 被引用数 (Scopus)

    抄録

    In meiosis, the accurate segregation of maternal and paternal chromosomes is accomplished by homologous recombination. A central player in meiotic recombination is the Dmc1 recombinase, a member of the RecA/Rad51 recombinase superfamily, which is widely conserved from viruses to humans. Dmc1 is a meiosis-specific protein that functions with the ubiquitously expressed homolog, the Rad51 recombinase, which is essential for both mitotic and meiotic recombination. Since its discovery, it has been speculated that Dmc1 is important for unique aspects of meiotic recombination. Understanding the distinctive properties of Dmc1, namely, the features that distinguish it from Rad51, will further clarify the mechanisms of meiotic recombination. Recent structural, biochemical, and genetic findings are now revealing the molecular mechanisms of Dmc1-mediated homologous recombination and its regulation by various recombination mediators.

    本文言語English
    ページ(範囲)590-598
    ページ数9
    ジャーナルFEBS Journal
    277
    3
    DOI
    出版ステータスPublished - 2010 2

    ASJC Scopus subject areas

    • 生化学
    • 細胞生物学
    • 分子生物学

    フィンガープリント

    「From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis-specific recombinase Dmc1」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル