Nine compounds (1-9) were isolated from the fruiting bodies of Stropharia rugosoannulata. Compounds 1-5, 8, and 9 suppressed the formation of osteoclast. Compounds 2 and 5 showed anti-fungal activity, and their MIC were 250μM and 500μM respectively. Compounds 2-6 showed inhibitory effects on thapsigargin toxicity.
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