Functionalized three-dimensional carbon microarrays for cancer biomarker detection

V. Penmatsa, A. R. Ruslinda, M. Beidaghi, H. Kawarada, C. Wang

研究成果: Conference contribution

8 引用 (Scopus)

抜粋

A label-free detection strategy for the detection of platelet-derived growth factor (PDGF-BB) oncoprotein detection using signaling aptamer/protein binding complex is reported. The 3D carbon microarrays detection platform was fabricated by pyrolyzing patterned photoresist and surface functionalized using directamination technique. The detection strategy is based on the release of TOTO intercalating dye from the target binding aptamer's stem structure when it captures PDGF. The sensor showed near linear relationship between the relative fluorescence difference and protein concentration with a very good detection limit of 5 pmol. This detection strategy is promising for the potential detection of different cancer biomarkers and proteins.

元の言語English
ホスト出版物のタイトルNano/Bio Sensors
ページ7-14
ページ数8
エディション15
DOI
出版物ステータスPublished - 2013 10 22
イベントSymposium on Nano/Bio Sensors - 221st ECS Meeting - Seattle, WA, United States
継続期間: 2012 5 62012 5 10

出版物シリーズ

名前ECS Transactions
番号15
45
ISSN(印刷物)1938-5862
ISSN(電子版)1938-6737

Conference

ConferenceSymposium on Nano/Bio Sensors - 221st ECS Meeting
United States
Seattle, WA
期間12/5/612/5/10

ASJC Scopus subject areas

  • Engineering(all)

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  • これを引用

    Penmatsa, V., Ruslinda, A. R., Beidaghi, M., Kawarada, H., & Wang, C. (2013). Functionalized three-dimensional carbon microarrays for cancer biomarker detection. : Nano/Bio Sensors (15 版, pp. 7-14). (ECS Transactions; 巻数 45, 番号 15). https://doi.org/10.1149/04515.0007ecst