Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

Yukio Sasaki*, Chi Cheng, Yutaka Uchida, Oumi Nakajima, Toshio Ohshima, Takeshi Yagi, Masahiko Taniguchi, Takashi Nakayama, Reiji Kishida, Yoshihisa Kudo, Shigeaki Ohno, Fumio Nakamura, Yoshio Goshima

*この研究の対応する著者

研究成果: Article査読

274 被引用数 (Scopus)

抄録

Semaphorin-3A (Sema3A), a member of class 3 semaphorins, regulates axon and dendrite guidance in the nervous system. How Sema3A and its receptors plexin-As and neuropilins regulate neuronal guidance is unknown. We observed that in fyn- and cdk5-deficient mice, Sema3A-induced growth cone collapse responses were attenuated compared to their heterologous controls. Cdk5 is associated with plexin-A2 through the active state of Fyn. Sema3A promotes Cdk5 activity through phosphorylation of Tyr15, a phosphorylation site with Fyn. A Cdk5 mutant (Tyr15 to Ala) shows a dominant-negative effect on the Sema3A-induced collapse response. The sema3A gene shows strong interaction with fyn for apical dendrite guidance in the cerebral cortex. We propose a signal transduction pathway in which Fyn and Cdk5 mediate neuronal guidance regulated by Sema3A.

本文言語English
ページ(範囲)907-920
ページ数14
ジャーナルNeuron
35
5
DOI
出版ステータスPublished - 2002 8 29
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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