Gene amplification: Mechanisms and involvement in cancer

Atsuka Matsui, Tatsuya Ihara, Hiraku Suda, Hirofumi Mikami, Kentaro Semba*

*この研究の対応する著者

研究成果: Review article査読

46 被引用数 (Scopus)

抄録

Gene amplification was recognized as a physiological process during the development of Drosophila melanogaster. Intriguingly, mammalian cells use this mechanism to overexpress particular genes for survival under stress, such as during exposure to cytotoxic drugs. One well-known example is the amplification of the dihydrofolate reductase gene observed in methotrexate- resistant cells. Four models have been proposed for the generation of amplifications: extrareplication and recombination, the breakage-fusion-bridge cycle, double rolling-circle replication, and replication fork stalling and template switching. Gene amplification is a typical genetic alteration in cancer, and historically many oncogenes have been identified in the amplified regions. In this regard, novel cancer-associated genes may remain to be identified in the amplified regions. Recent comprehensive approaches have further revealed that co-amplified genes also contribute to tumorigenesis in concert with known oncogenes in the same amplicons. Considering that cancer develops through the alteration of multiple genes, gene amplification is an effective acceleration machinery to promote tumorigenesis. Identification of cancer-associated genes could provide novel and effective therapeutic targets.

本文言語English
ページ(範囲)567-582
ページ数16
ジャーナルBiomolecular Concepts
4
6
DOI
出版ステータスPublished - 2013 12 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)
  • 細胞および分子神経科学

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