Genome sequence of the endocellular obligate symbiont of tsetse flies, Wigglesworthia glossinidia

Leyla Akman, Atsushi Yamashita, Hidemi Watanabe, Kenshiro Oshima, Tadayoshi Shiba, Masahira Hattori, Serap Aksoy

研究成果: Article査読

442 被引用数 (Scopus)

抄録

Many insects that rely on a single food source throughout their developmental cycle harbor beneficial microbes that provide nutrients absent from their restricted diet. Tsetse flies, the vectors of African trypanosomes, feed exclusively on blood and rely on one such intracellular microbe for nutritional provisioning and fecundity. As a result of co-evolution with hosts over millions of years, these mutualists have lost the ability to survive outside the sheltered environment of their host insect cells. We present the complete annotated genome of Wigglesworthia glossinidia brevipalpis, which is composed of one chromosome of 697,724 base pairs (bp) and one small plasmid, called pWig1, of 5,200 bp. Genes involved in the biosynthesis of vitamin metabolites, apparently essential for host nutrition and fecundity, have been retained. Unexpectedly, this obligate's genome bears hallmarks of both parasitic and free-living microbes, and the gene encoding the important regulatory protein DnaA is absent.

本文言語English
ページ(範囲)402-407
ページ数6
ジャーナルNature Genetics
32
3
DOI
出版ステータスPublished - 2002 11 1
外部発表はい

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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