TY - JOUR
T1 - GnIH control of feeding and reproductive behaviors
AU - Tsutsui, Kazuyoshi
AU - Ubuka, Takayoshi
PY - 2016
Y1 - 2016
N2 - In 2000, Tsutsui and colleagues discovered a neuropeptide gonadotropin-inhibitory hormone (GnIH) that inhibits gonadotropin release in birds. Subsequently, extensive studies during the last 15 years have demonstrated that GnIH is a key neurohormone that regulates reproduction in vertebrates, acting in the brain and on the pituitary to modulate reproduction and reproductive behavior. On the other hand, deprivation of food and other metabolic challenges inhibit the reproductive axis as well as sexual motivation. Interestingly, recent studies have further indicated that GnIH controls feeding behavior in vertebrates, such as in birds and mammals. This review summarizes the discovery of GnIH and its conservation in vertebrates and the neuroendocrine control of feeding behavior and reproductive behavior by GnIH.
AB - In 2000, Tsutsui and colleagues discovered a neuropeptide gonadotropin-inhibitory hormone (GnIH) that inhibits gonadotropin release in birds. Subsequently, extensive studies during the last 15 years have demonstrated that GnIH is a key neurohormone that regulates reproduction in vertebrates, acting in the brain and on the pituitary to modulate reproduction and reproductive behavior. On the other hand, deprivation of food and other metabolic challenges inhibit the reproductive axis as well as sexual motivation. Interestingly, recent studies have further indicated that GnIH controls feeding behavior in vertebrates, such as in birds and mammals. This review summarizes the discovery of GnIH and its conservation in vertebrates and the neuroendocrine control of feeding behavior and reproductive behavior by GnIH.
KW - Feeding behavior
KW - Gonadotropin-inhibitory hormone
KW - Gonadotropin-releasing hormone
KW - Gonadotropins
KW - Reproduction
KW - Reproductive behavior
UR - http://www.scopus.com/inward/record.url?scp=85008149976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008149976&partnerID=8YFLogxK
U2 - 10.3389/fendo.2016.00170
DO - 10.3389/fendo.2016.00170
M3 - Review article
AN - SCOPUS:85008149976
VL - 7
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
IS - DEC
M1 - 170
ER -