Gold(I)-catalyzed 10-endo-dig-selective cycloisomerization of N-(2-anilinobenzyl)propargylamines

Mamoru Ito, Daisuke Inoue, Asahi Takaki, Kyalo Stephen Kanyiva, Takanori Shibata

研究成果: Article査読

抄録

– The cationic gold(I)-catalyzed 10-endo-dig-selective cycloisomerization of N-(2-anilinobenzyl)propargylamine derivatives was developed. The reaction proceeded smoothly under mild conditions to give dibenzodiazecines. The catalytic construction of an entropically and enthalpically disfavored ten-membered ring was achieved by using a highly nucleophilic 3,5-dimethoxyanilino group as a reaction site.

本文言語English
ページ(範囲)195-208
ページ数14
ジャーナルHeterocycles
101
1
DOI
出版ステータスPublished - 2020

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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