Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3: Discovery and functional implications for reproduction and stress

L. J. Kriegsfeld*, K. J. Jennings, G. E. Bentley, Kazuyoshi Tsutsui

*この研究の対応する著者

    研究成果: Review article査読

    15 被引用数 (Scopus)

    抄録

    At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian pituitary gonadotrophin secretion was identified and named gonadotrophin-inhibitory hormone (GnIH). Across bird species, GnIH acts at the level of the pituitary and the gonadotrophin-releasing hormone (GnRH) neuronal system to inhibit reproduction. Subsequent to this initial discovery, orthologues of GnIH have been identified and characterised across a broad range of species. In many vertebrates, the actions of GnIH and its orthologues serve functional roles analogous to those seen in birds. In other cases, GnIH and its orthologues exhibit more diverse actions dependent on sex, species, season and reproductive condition. The present review highlights the discovery and functional implications of GnIH across species, focusing on research domains in which the significance of this neuropeptide has been explored most.

    本文言語English
    論文番号e12597
    ジャーナルJournal of Neuroendocrinology
    30
    7
    DOI
    出版ステータスPublished - 2018 7 1

    ASJC Scopus subject areas

    • 内分泌学、糖尿病および代謝内科学
    • 内分泌学
    • 内分泌系および自律システム
    • 細胞および分子神経科学

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