Gonadotrophin inhibitory hormone depresses gonadotrophin α and follicle-stimulating hormone β subunit expression in the pituitary of the domestic chicken

Nick A. Ciccone*, I. C. Dunn, T. Boswell, Kazuyoshi Tsutsui, T. Ubuka, K. Ukena, P. J. Sharp

*この研究の対応する著者

研究成果: Article査読

151 被引用数 (Scopus)

抄録

Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest-deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short-term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle-stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out-of-lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out-of-lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken.

本文言語English
ページ(範囲)999-1006
ページ数8
ジャーナルJournal of Neuroendocrinology
16
12
DOI
出版ステータスPublished - 2004 12月
外部発表はい

ASJC Scopus subject areas

  • 内分泌学
  • 神経科学(全般)

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