Gracilioethers A-C, antimalarial metabolites from the marine sponge Agelas gracilis

Reiko Ueoka, Yoichi Nakao, Shizuka Kawatsu, Junko Yaegashi, Yoshitsugu Matsumoto, Shigeki Matsunaga, Kazuo Furihata, Rob W.M. Van Soest, Nobuhiro Fusetani

研究成果: Article査読

50 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Three new antiprotozoan compounds, gracilioethers A-C (1-3), have been isolated from the marine sponge Agelas gracilis. Their structures were elucidated on the basis of spectroscopic and chemical methods. Gracilioethers A-C showed antimalarial activity against Plasmodium falciparum with IC50 values of 0.5-10 μg/mL, whereas gracilioether B (2) also showed antileishmanial activity.

本文言語English
ページ(範囲)4203-4207
ページ数5
ジャーナルJournal of Organic Chemistry
74
11
DOI
出版ステータスPublished - 2009 6 5

ASJC Scopus subject areas

  • 有機化学

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