Haemoglobin-vesicles as artificial oxygen carriers: Present situation and future visions

H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida

研究成果: Article査読

64 被引用数 (Scopus)

抄録

During the long history of development of haemoglobin (Hb)-based O 2 carriers (HBOCs), many side effects of Hb molecules have become apparent. They imply the physiological importance of the cellular structure of red blood cells. Hb-vesicles (HbV) are artificial O2 carriers that encapsulate concentrated Hb solution with a thin lipid membrane. We have overcome the intrinsic issues of the suspension of HbV as a molecular assembly, such as stability for storage and in blood circulation, blood compatibility and prompt degradation in the reticuloendothelial system. Animal tests clarified the efficacy of HbV as a transfusion alternative and the possibility for other clinical applications. The results of ongoing HbV research make us confident in advancing further development of HbV, with the expectation of its eventual realization.

本文言語English
ページ(範囲)4-15
ページ数12
ジャーナルJournal of Internal Medicine
263
1
DOI
出版ステータスPublished - 2008 1

ASJC Scopus subject areas

  • Internal Medicine

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