TY - JOUR
T1 - Haemoglobin-vesicles as artificial oxygen carriers
T2 - Present situation and future visions
AU - Sakai, H.
AU - Sou, K.
AU - Horinouchi, H.
AU - Kobayashi, K.
AU - Tsuchida, E.
PY - 2008/1
Y1 - 2008/1
N2 - During the long history of development of haemoglobin (Hb)-based O 2 carriers (HBOCs), many side effects of Hb molecules have become apparent. They imply the physiological importance of the cellular structure of red blood cells. Hb-vesicles (HbV) are artificial O2 carriers that encapsulate concentrated Hb solution with a thin lipid membrane. We have overcome the intrinsic issues of the suspension of HbV as a molecular assembly, such as stability for storage and in blood circulation, blood compatibility and prompt degradation in the reticuloendothelial system. Animal tests clarified the efficacy of HbV as a transfusion alternative and the possibility for other clinical applications. The results of ongoing HbV research make us confident in advancing further development of HbV, with the expectation of its eventual realization.
AB - During the long history of development of haemoglobin (Hb)-based O 2 carriers (HBOCs), many side effects of Hb molecules have become apparent. They imply the physiological importance of the cellular structure of red blood cells. Hb-vesicles (HbV) are artificial O2 carriers that encapsulate concentrated Hb solution with a thin lipid membrane. We have overcome the intrinsic issues of the suspension of HbV as a molecular assembly, such as stability for storage and in blood circulation, blood compatibility and prompt degradation in the reticuloendothelial system. Animal tests clarified the efficacy of HbV as a transfusion alternative and the possibility for other clinical applications. The results of ongoing HbV research make us confident in advancing further development of HbV, with the expectation of its eventual realization.
KW - Artificial oxygen carrier
KW - Biocompatibility
KW - Liposome
KW - Nanotechnology
KW - Polyethylene glycol
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U2 - 10.1111/j.1365-2796.2007.01893.x
DO - 10.1111/j.1365-2796.2007.01893.x
M3 - Article
C2 - 18042220
AN - SCOPUS:36949017465
SN - 0954-6820
VL - 263
SP - 4
EP - 15
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
IS - 1
ER -