Haemoglobin-vesicles as artificial oxygen carriers: Present situation and future visions

H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi, E. Tsuchida

研究成果: Article

60 引用 (Scopus)

抄録

During the long history of development of haemoglobin (Hb)-based O 2 carriers (HBOCs), many side effects of Hb molecules have become apparent. They imply the physiological importance of the cellular structure of red blood cells. Hb-vesicles (HbV) are artificial O2 carriers that encapsulate concentrated Hb solution with a thin lipid membrane. We have overcome the intrinsic issues of the suspension of HbV as a molecular assembly, such as stability for storage and in blood circulation, blood compatibility and prompt degradation in the reticuloendothelial system. Animal tests clarified the efficacy of HbV as a transfusion alternative and the possibility for other clinical applications. The results of ongoing HbV research make us confident in advancing further development of HbV, with the expectation of its eventual realization.

元の言語English
ページ(範囲)4-15
ページ数12
ジャーナルJournal of Internal Medicine
263
発行部数1
DOI
出版物ステータスPublished - 2008 1

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Hemoglobins
Oxygen
Blood Substitutes
Mononuclear Phagocyte System
Blood Circulation
Cellular Structures
Membrane Lipids
Suspensions
Erythrocytes
History
Research

ASJC Scopus subject areas

  • Internal Medicine

これを引用

Haemoglobin-vesicles as artificial oxygen carriers : Present situation and future visions. / Sakai, H.; Sou, K.; Horinouchi, H.; Kobayashi, K.; Tsuchida, E.

:: Journal of Internal Medicine, 巻 263, 番号 1, 01.2008, p. 4-15.

研究成果: Article

Sakai, H. ; Sou, K. ; Horinouchi, H. ; Kobayashi, K. ; Tsuchida, E. / Haemoglobin-vesicles as artificial oxygen carriers : Present situation and future visions. :: Journal of Internal Medicine. 2008 ; 巻 263, 番号 1. pp. 4-15.
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