We have studied prototypes of platelet substitutes by conjugating the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen, to the surface of polymerized albumin particles (polyAlb) or phospholipid vesicles (vesicle). Both H12-polyAlb and H12-vesicle showed a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. The H12-polyAlb was more effective than the H12-vesicle.
|出版ステータス||Published - 2005 12 1|
|イベント||54th SPSJ Annual Meeting 2005 - Yokohama, Japan|
継続期間: 2005 5 25 → 2005 5 27
|Conference||54th SPSJ Annual Meeting 2005|
|Period||05/5/25 → 05/5/27|
ASJC Scopus subject areas