Haemostatic effects of polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide as platelet substitutes in vitro and in vivo

Yosuke Okamura, Toshinori Fujie, Makoto Handa, Yasuo Ikeda, Shinji Takeoka

研究成果: Paper

抜粋

We have studied prototypes of platelet substitutes and focused on the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen as activated platelets, and conjugated H12 to the surface of polymerized albumin particles (polyAlb) as biocompatible and biodegradable particles. The H12-conjugated polyAlb (H12-polyAlb) adding to the thrombocytopenic-imitation blood enhanced the platelet thrombus formation on a collagen-plate in vitro. We confirmed that H12-polyAlb had a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. H12-polyAlb is a suitable candidate for an alternative to human platelet concentrates infused into thrombocytopenic patients.

元の言語English
ページ4933-4934
ページ数2
出版物ステータスPublished - 2005 12 1
イベント54th SPSJ Symposium on Macromolecules - Yamagata, Japan
継続期間: 2005 9 202005 9 22

Other

Other54th SPSJ Symposium on Macromolecules
Japan
Yamagata
期間05/9/2005/9/22

    フィンガープリント

ASJC Scopus subject areas

  • Engineering(all)

これを引用

Okamura, Y., Fujie, T., Handa, M., Ikeda, Y., & Takeoka, S. (2005). Haemostatic effects of polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide as platelet substitutes in vitro and in vivo. 4933-4934. 論文発表場所 54th SPSJ Symposium on Macromolecules, Yamagata, Japan.