We have studied prototypes of platelet substitutes and focused on the dodecapeptide (H12); a part of the amino acid sequence of fibrinogen as activated platelets, and conjugated H12 to the surface of polymerized albumin particles (polyAlb) as biocompatible and biodegradable particles. The H12-conjugated polyAlb (H12-polyAlb) adding to the thrombocytopenic-imitation blood enhanced the platelet thrombus formation on a collagen-plate in vitro. We confirmed that H12-polyAlb had a hemostatic effect, based on the analysis of the tail bleeding time of thrombocytopenic rats. H12-polyAlb is a suitable candidate for an alternative to human platelet concentrates infused into thrombocytopenic patients.
|出版ステータス||Published - 2005 12 1|
|イベント||54th SPSJ Symposium on Macromolecules - Yamagata, Japan|
継続期間: 2005 9 20 → 2005 9 22
|Other||54th SPSJ Symposium on Macromolecules|
|Period||05/9/20 → 05/9/22|
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