抄録
Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.
本文言語 | English |
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ページ(範囲) | 273-278 |
ページ数 | 6 |
ジャーナル | Journal of Antibiotics |
巻 | 71 |
号 | 2 |
DOI | |
出版ステータス | Published - 2018 2 1 |
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery