Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura; Norio Kudo; Yuki Tomachi; Akiko Nakata; Misao Takemoto; Akihiro Ito; Hodaka Tabei; Daisuke Arai; Nicole De Voogd; Minoru Yoshida; Yoichi Nakao; Nobuhiro Fusetani

doi:10.1038/ja.2017.145

Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

Fumiaki Nakamura, Norio Kudo, Yuki Tomachi, Akiko Nakata, Misao Takemoto, Akihiro Ito, Hodaka Tabei, Daisuke Arai, Nicole De Voogd, Minoru Yoshida, Yoichi Nakao, Nobuhiro Fusetani

先進理工学部

研究成果: Article › 査読

11 被引用数 (Scopus)

抄録

Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.

本文言語	English
ページ（範囲）	273-278
ページ数	6
ジャーナル	Journal of Antibiotics
巻	71
号	2
DOI	https://doi.org/10.1038/ja.2017.145
出版ステータス	Published - 2018 2 1

ASJC Scopus subject areas

Pharmacology
Drug Discovery

文献へのアクセス

10.1038/ja.2017.145

フィンガープリント「Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria. / Nakamura, Fumiaki; Kudo, Norio; Tomachi, Yuki; Nakata, Akiko; Takemoto, Misao; Ito, Akihiro; Tabei, Hodaka; Arai, Daisuke; De Voogd, Nicole; Yoshida, Minoru; Nakao, Yoichi; Fusetani, Nobuhiro.

In: Journal of Antibiotics, Vol. 71, No. 2, 01.02.2018, p. 273-278.

研究成果: Article › 査読

Nakamura, Fumiaki ; Kudo, Norio ; Tomachi, Yuki ; Nakata, Akiko ; Takemoto, Misao ; Ito, Akihiro ; Tabei, Hodaka ; Arai, Daisuke ; De Voogd, Nicole ; Yoshida, Minoru ; Nakao, Yoichi ; Fusetani, Nobuhiro. / Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria. In: Journal of Antibiotics. 2018 ; Vol. 71, No. 2. pp. 273-278.

@article{14ec5da506684c1599f0501c4f2be1a5,

title = "Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria",

abstract = "Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.",

author = "Fumiaki Nakamura and Norio Kudo and Yuki Tomachi and Akiko Nakata and Misao Takemoto and Akihiro Ito and Hodaka Tabei and Daisuke Arai and {De Voogd}, Nicole and Minoru Yoshida and Yoichi Nakao and Nobuhiro Fusetani",

year = "2018",

month = feb,

day = "1",

doi = "10.1038/ja.2017.145",

language = "English",

volume = "71",

pages = "273--278",

journal = "Journal of Antibiotics",

issn = "0021-8820",

publisher = "Japan Antibiotics Research Association",

number = "2",

}

TY - JOUR

T1 - Halistanol sulfates i and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria

AU - Nakamura, Fumiaki

AU - Kudo, Norio

AU - Tomachi, Yuki

AU - Nakata, Akiko

AU - Takemoto, Misao

AU - Ito, Akihiro

AU - Tabei, Hodaka

AU - Arai, Daisuke

AU - De Voogd, Nicole

AU - Yoshida, Minoru

AU - Nakao, Yoichi

AU - Fusetani, Nobuhiro

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.

AB - Two new analogs of halistanol sulfate (1) were isolated from a marine sponge Halichondria sp. collected at Hachijo-jima Island. Structures of these new halistanol sulfates I (2) and J (3) were elucidated by spectral analyses. Compounds 1-3 showed inhibitory activity against SIRT 1-3 with IC 50 ranges of 45.9-67.9, 18.9-21.1 and 21.8-37.5 μM, respectively. X-ray crystallography of the halistanol sulfate (1) and SIRT3 complex clearly indicates that 1 binds to the exosite of SIRT3 that we have discovered in this study.

UR - http://www.scopus.com/inward/record.url?scp=85041183800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041183800&partnerID=8YFLogxK

U2 - 10.1038/ja.2017.145

DO - 10.1038/ja.2017.145

M3 - Article

C2 - 29184120

AN - SCOPUS:85041183800

VL - 71

SP - 273

EP - 278

JO - Journal of Antibiotics

JF - Journal of Antibiotics

SN - 0021-8820

IS - 2

ER -