Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794

Takuya Suga, Tōru Kimura, Yuki Inahashi, Masato Iwatsuki, Kenichi Nonaka, Akira Take, Atsuko Matsumoto, Yōko Takahashi, Satoshi Omura, Takuji Nakashima

研究成果: Article

2 引用 (Scopus)

抄録

Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.

元の言語English
ページ(範囲)619-625
ページ数7
ジャーナルJournal of Antibiotics
71
発行部数7
DOI
出版物ステータスPublished - 2018 7 1
外部発表Yes

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Actinobacteria
Macrolides
Xanthomonas
Silica Gel
Gel Chromatography
High Pressure Liquid Chromatography
Cell Line
Growth
Oryza

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

これを引用

Suga, T., Kimura, T., Inahashi, Y., Iwatsuki, M., Nonaka, K., Take, A., ... Nakashima, T. (2018). Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. Journal of Antibiotics, 71(7), 619-625. https://doi.org/10.1038/s41429-018-0055-x

Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. / Suga, Takuya; Kimura, Tōru; Inahashi, Yuki; Iwatsuki, Masato; Nonaka, Kenichi; Take, Akira; Matsumoto, Atsuko; Takahashi, Yōko; Omura, Satoshi; Nakashima, Takuji.

:: Journal of Antibiotics, 巻 71, 番号 7, 01.07.2018, p. 619-625.

研究成果: Article

Suga, T, Kimura, T, Inahashi, Y, Iwatsuki, M, Nonaka, K, Take, A, Matsumoto, A, Takahashi, Y, Omura, S & Nakashima, T 2018, 'Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794', Journal of Antibiotics, 巻. 71, 番号 7, pp. 619-625. https://doi.org/10.1038/s41429-018-0055-x
Suga, Takuya ; Kimura, Tōru ; Inahashi, Yuki ; Iwatsuki, Masato ; Nonaka, Kenichi ; Take, Akira ; Matsumoto, Atsuko ; Takahashi, Yōko ; Omura, Satoshi ; Nakashima, Takuji. / Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794. :: Journal of Antibiotics. 2018 ; 巻 71, 番号 7. pp. 619-625.
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