Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794

Takuya Suga*, Tōru Kimura, Yuki Inahashi, Masato Iwatsuki, Kenichi Nonaka, Akira Také, Atsuko Matsumoto, Yōko Takahashi, Satoshi Omura, Takuji Nakashima

*この研究の対応する著者

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.

本文言語English
ページ(範囲)619-625
ページ数7
ジャーナルJournal of Antibiotics
71
7
DOI
出版ステータスPublished - 2018 7月 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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