Hematopoietic growth factors

Takashi Kato*

*この研究の対応する著者

研究成果: Chapter

抄録

Hematopoietic growth factors have the ability to promote the proliferation and differentiation of hematopoietic progenitors derived from hematopoietic stem cells in hematopoietic lineages. The common structural feature displays a four-α-helical bundle structure. The phylogeny and evolution of the molecular structure have been studied extensively. Receptors for most hematopoietic growth factors belong to type I cytokine receptors that do not have tyrosine kinase activity, and share common properties. The ligand-receptor binding triggers changes of the intracellular conformation of the receptor complex, and initiates multiple signaling cascades to promote survival, proliferation, and differentiation. Hematopoietic growth factors are classified into two groups, intermediate-acting lineage-nonspecific factors and late-acting lineage-specific factors. Clinical applications of recombinant factors and receptor antagonists/agonists have been well established.

本文言語English
ホスト出版物のタイトルHandbook of Hormones
ホスト出版物のサブタイトルComparative Endocrinology for Basic and Clinical Research
出版社Elsevier
ページ453-455
ページ数3
ISBN(電子版)9780128206492
DOI
出版ステータスPublished - 2021 1月 1

ASJC Scopus subject areas

  • 医学(全般)

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