Hepatocyte nuclear factor 1 beta induces transformation and epithelial-to-mesenchymal transition

Atsuka Matsui, Jiro Fujimoto, Kosuke Ishikawa, Emi Ito, Naoki Goshima, Shinya Watanabe, Kentaro Semba

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12-21 amplicon, which contains ERBB2. We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial-to-mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2.

本文言語English
ページ(範囲)1211-1221
ページ数11
ジャーナルFEBS Letters
590
8
DOI
出版ステータスPublished - 2016 4 1

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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