High-frequency sarcomeric auto-oscillations induced by heating in living neonatal cardiomyocytes of the rat

Seine A. Shintani, Kotaro Oyama, Norio Fukuda, ShiN'Ichi Ishiwata

    研究成果: Article

    14 引用 (Scopus)

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    In the present study, we investigated the effects of infra-red laser irradiation on sarcomere dynamics in living neonatal cardiomyocytes of the rat. A rapid increase in temperature to >∼38°C induced [Ca2+]i-independent high-frequency (∼5-10 Hz) sarcomeric auto-oscillations (Hyperthermal Sarcomeric Oscillations; HSOs). In myocytes with the intact sarcoplasmic reticular functions, HSOs coexisted with [Ca2+]i-dependent spontaneous beating in the same sarcomeres, with markedly varying frequencies (∼10 and ∼1 Hz for the former and latter, respectively). HSOs likewise occurred following blockade of the sarcoplasmic reticular functions, with the amplitude becoming larger and the frequency lower in a time-dependent manner. The present findings suggest that in the mammalian heart, sarcomeres spontaneously oscillate at higher frequencies than the sinus rhythm at temperatures slightly above the physiologically relevant levels.

    元の言語English
    ページ(範囲)165-170
    ページ数6
    ジャーナルBiochemical and Biophysical Research Communications
    457
    発行部数2
    DOI
    出版物ステータスPublished - 2015 2 6

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    ASJC Scopus subject areas

    • Biochemistry
    • Biophysics
    • Cell Biology
    • Molecular Biology

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