Highly chemo-, enantio-, and regioselective synthesis of α,α-disubstituted furanones by Cu-catalyzed conjugate addition

Kohei Endo, Sayuri Yakeishi, Ryotaro Takayama, Takanori Shibata

研究成果: Article査読

13 被引用数 (Scopus)

抄録

A highly chemo-, enantio-, and regioselective synthesis of furanones bearing an α,α-disubstituted quaternary stereogenic center is reported. The Cu-catalyzed enantioselective conjugate addition of organoaluminum reagents to unsaturated ketoesters at room temperature and subsequent lactonization took place. Synthetic transformations of furanones represent facile approaches to various cyclic or acyclic compounds bearing a quaternary stereogenic center. Selective chemistry: A highly chemo-, enantio-, and regioselective synthesis of furanones bearing an α,α-disubstituted quaternary stereogenic center is reported (see scheme). Cu-catalyzed enantioselective conjugate addition of organoaluminum reagents to unsaturated ketoesters at room temperature and subsequent lactonization took place.

本文言語English
ページ(範囲)8893-8897
ページ数5
ジャーナルChemistry - A European Journal
20
29
DOI
出版ステータスPublished - 2014 7 14

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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