Highly enantioselective construction of a chiral spirocyclic structure by the [2 + 2 + 2] cycloaddition of diynes and exo-methylene cyclic compounds

Kyoji Tsuchikama, Yusuke Kuwata, Takanori Shibata

    研究成果: Article

    66 引用 (Scopus)

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    The enantioselective [2 + 2 + 2] cycloaddition of 1,6-diynes with α-methylene lactones and cyclic ketones gave various chiral spirocyclic compounds. The reaction proceeded with high enantioselectivity when the rhodium-xylylBINAP complex was used as a chiral catalyst. Not only exo-methylene cyclic compounds but also exo-methylene acyclic compounds could be used as coupling partners for diynes. The present protocol provides access to a new chiral library possessing a quaternary carbon center, including a spirocyclic system.

    元の言語English
    ページ(範囲)13686-13687
    ページ数2
    ジャーナルJournal of the American Chemical Society
    128
    発行部数42
    DOI
    出版物ステータスPublished - 2006 10 25

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    ASJC Scopus subject areas

    • Chemistry(all)

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