Highly enantioselective reduction with novel, bridged NADH models

N. Kanomata*, T. Nakata

*この研究の対応する著者

研究成果: Article査読

81 被引用数 (Scopus)

抄録

Biomimetic reduction of benzoylformate to mandelate with 97-99% ee was achieved with the diastereomeric, bridged NADH models (S.S)-1 and (R.S)-1. The oligomethylene bridge acts as an 'enzyme wall' and hinders the approach of the substrate from one side of the dihydropyridine ring. Isomers 1 were synthesized from the corresponding bridged nicotinate precursor, which was prepared by the reaction of formyl-substituted (vinylimino)phosphorane with methyl propiolate.

本文言語English
ページ(範囲)1207-1211
ページ数5
ジャーナルAngewandte Chemie - International Edition in English
36
11
DOI
出版ステータスPublished - 1997 1月 1
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

フィンガープリント

「Highly enantioselective reduction with novel, bridged NADH models」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル