Highly sensitive microbiosensor for creatinine based on the combination of inactive polypyrrole with polyion complexes

Tetsuya Osaka*, Shinichi Komaba, Akio Amano

*この研究の対応する著者

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Potentiometric creatinine microsensors were fabricated by use of a composite film consisting of polyion complex (PIC) which contains creatinine iminohydrolase (CIH), and the electrochemically inactive polypyrrole (iPPy). The PPy/PIC-CIH composite film electrode displayed potential response to creatinine concentration owing to a pH change occurring during the enzymatic reaction. The sensitivity was varied by using different polyions of the PIC. With poly-L-lysine and sebacic acid, the iPPy/PIC-CIH electrode demonstrated a high sensitivity (29.8 mV decade-1) and a low detection limit (1 × 10-6 mol dm-3), which allow one to monitor creatinine concentration in the physiological range.

本文言語English
ページ(範囲)406-408
ページ数3
ジャーナルJournal of the Electrochemical Society
145
2
DOI
出版ステータスPublished - 1998 2

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 再生可能エネルギー、持続可能性、環境
  • 表面、皮膜および薄膜
  • 電気化学
  • 材料化学

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