Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea

Junnosuke Otaka, Daisuke Hashizume, Yui Masumoto, Atsuya Muranaka, Masanobu Uchiyama, Hiroyuki Koshino, Yushi Futamura, Hiroyuki Osada*

*この研究の対応する著者

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Hitoyol A (1), an unprecedented norsesquiterpenoid with an exo-tricyclo[5.2.1.02,6]decane skeleton, was isolated from the culture broth of Basidiomycete Coprinopsis cinerea along with a novel skeletal hitoyol B (2) containing 4-cyclopentene-1,3-dione. Their structures and absolute configurations were analyzed by single-crystal X-ray diffraction and electronic circular dichroism spectroscopic methods. Compound 1 is possibly biosynthesized through decarboxylation-induced cyclization of lagopodin B, a known cuparene-type sesquiterpenoid. Compound 2 showed weak antimalarial activity with an IC50 of 59 μM.

本文言語English
ページ(範囲)4030-4033
ページ数4
ジャーナルOrganic Letters
19
15
DOI
出版ステータスPublished - 2017 8月 4
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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