HLA-VBSeq v2: improved HLA calling accuracy with full-length Japanese class-I panel

Yen Yen Wang, Takahiro Mimori, Seik Soon Khor, Olivier Gervais, Yosuke Kawai, Yuki Hitomi, Katsushi Tokunaga, Masao Nagasaki*

*この研究の対応する著者

研究成果: Article査読

6 被引用数 (Scopus)

抄録

HLA-VBSeq is an HLA calling tool developed to infer the most likely HLA types from high-throughput sequencing data. However, there is still room for improvement in specific genetic groups because of the diversity of HLA alleles in human populations. Here, we present HLA-VBSeq v2, a software application that makes use of a new Japanese HLA reference panel to enhance calling accuracy for Japanese HLA class-I genes. Our analysis showed significant improvements in calling accuracy in all HLA regions, with prediction accuracies achieving over 99.0, 97.8, and 99.8% in HLA-A, B and C, respectively.

本文言語English
論文番号29
ジャーナルHuman Genome Variation
6
1
DOI
出版ステータスPublished - 2019 12月 1
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 遺伝学

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