Hormesis and exercise: How the cell copes with oxidative stress

Li Li Ji*, Zsolt Radak, Sataro Goto

*この研究の対応する著者

研究成果: Review article査読

17 被引用数 (Scopus)

抄録

Contraction-induced production of reactive oxygen and nitrogen species has been shown to cause oxidative stress to skeletal muscle, heart and other organs. As an adaptive response, muscle antioxidant defense systems are upregulated in response to exercise to restore intracellular prooxidant-antioxidant homeostasis. Thus, both young and old animals and humans involved in regular exercise have shown reduced oxidative damage during acute physical exertion at accustomed or excessive intensity, or under oxidative challenges otherwise deemed detrimental. The current article provides a brief review of this exercise-induced hormesis with the emphasis on the role of redox sensitive signal transduction pathways (mainly nuclear factor κB and mitogen-activated protein kinase) that can activate the gene expression of antioxidant enzymes and proteins. Molecular mechanisms and gene targets for these signaling pathways, as well as the biological significance of the adaptations, are discussed.

本文言語English
ページ(範囲)41-55
ページ数15
ジャーナルAmerican Journal of Pharmacology and Toxicology
3
1
DOI
出版ステータスPublished - 2008
外部発表はい

ASJC Scopus subject areas

  • 薬理学、毒性学および薬学(全般)
  • 薬理学(医学)

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