fgr is a member of the protein kinase oncogene family and was found to have the highest homology to yes gene among the members of the family. Using a v-yes probe, a molecular clone of human c-fgr locus was isolated from a genomic library. Nucleotide sequence determination revealed that the actin gene-like sequence found in v-fgr gene was absent at the corresponding position of the c-fgr gene. Thus, the v-fgr gene product is considered to be a tri-chimeric gene product consisting of viral gag gene and two distinct cellular genes, actin gene and the proto-fgr gene.
|ジャーナル||Japanese Journal of Cancer Research GANN|
|出版ステータス||Published - 1985 1 1|
ASJC Scopus subject areas
- Cancer Research