抄録
Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here - nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence - provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.
元の言語 | English |
---|---|
ページ(範囲) | 497-500 |
ページ数 | 4 |
ジャーナル | Nature |
巻 | 440 |
発行部数 | 7083 |
DOI | |
出版物ステータス | Published - 2006 3 23 |
外部発表 | Yes |
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ASJC Scopus subject areas
- General
これを引用
Human chromosome 11 DNA sequence and analysis including novel gene identification. / Taylor, Todd D.; Noguchi, Hideki; Totoki, Yasushi; Toyoda, Atsushi; Kuroki, Yoko; Dewar, Ken; Lloyd, Christine; Itoh, Takehiko; Takeda, Tadayuki; Kim, Dae Won; She, Xinwei; Barlow, Karen F.; Bloom, Toby; Bruford, Elspeth; Chang, Jean L.; Cuomo, Christina A.; Eichler, Evan; FitzGerald, Michael G.; Jaffe, David B.; LaButti, Kurt; Nicol, Robert; Park, Hong Seog; Seaman, Christopher; Sougnez, Carrie; Yang, Xiaoping; Zimmer, Andrew R.; Zody, Michael C.; Birren, Bruce W.; Nusbaum, Chad; Fujiyama, Asao; Hattori, Masahira; Rogers, Jane; Lander, Eric S.; Sakaki, Yoshiyuki.
:: Nature, 巻 440, 番号 7083, 23.03.2006, p. 497-500.研究成果: Article
}
TY - JOUR
T1 - Human chromosome 11 DNA sequence and analysis including novel gene identification
AU - Taylor, Todd D.
AU - Noguchi, Hideki
AU - Totoki, Yasushi
AU - Toyoda, Atsushi
AU - Kuroki, Yoko
AU - Dewar, Ken
AU - Lloyd, Christine
AU - Itoh, Takehiko
AU - Takeda, Tadayuki
AU - Kim, Dae Won
AU - She, Xinwei
AU - Barlow, Karen F.
AU - Bloom, Toby
AU - Bruford, Elspeth
AU - Chang, Jean L.
AU - Cuomo, Christina A.
AU - Eichler, Evan
AU - FitzGerald, Michael G.
AU - Jaffe, David B.
AU - LaButti, Kurt
AU - Nicol, Robert
AU - Park, Hong Seog
AU - Seaman, Christopher
AU - Sougnez, Carrie
AU - Yang, Xiaoping
AU - Zimmer, Andrew R.
AU - Zody, Michael C.
AU - Birren, Bruce W.
AU - Nusbaum, Chad
AU - Fujiyama, Asao
AU - Hattori, Masahira
AU - Rogers, Jane
AU - Lander, Eric S.
AU - Sakaki, Yoshiyuki
PY - 2006/3/23
Y1 - 2006/3/23
N2 - Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here - nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence - provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.
AB - Chromosome 11, although average in size, is one of the most gene- and disease-rich chromosomes in the human genome. Initial gene annotation indicates an average gene density of 11.6 genes per megabase, including 1,524 protein-coding genes, some of which were identified using novel methods, and 765 pseudogenes. One-quarter of the protein-coding genes shows overlap with other genes. Of the 856 olfactory receptor genes in the human genome, more than 40% are located in 28 single- and multi-gene clusters along this chromosome. Out of the 171 disorders currently attributed to the chromosome, 86 remain for which the underlying molecular basis is not yet known, including several mendelian traits, cancer and susceptibility loci. The high-quality data presented here - nearly 134.5 million base pairs representing 99.8% coverage of the euchromatic sequence - provide scientists with a solid foundation for understanding the genetic basis of these disorders and other biological phenomena.
UR - http://www.scopus.com/inward/record.url?scp=33645276548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645276548&partnerID=8YFLogxK
U2 - 10.1038/nature04632
DO - 10.1038/nature04632
M3 - Article
C2 - 16554811
AN - SCOPUS:33645276548
VL - 440
SP - 497
EP - 500
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7083
ER -