Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

Shoko Hoshina; Kei Yura; Honami Teranishi; Noriko Kiyasu; Ayumi Tominaga; Haruka Kadoma; Ayaka Nakatsuka; Tomoko Kunichika; Chikashi Obuse; Shou Waga

doi:10.1074/jbc.M113.492504

Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

Shoko Hoshina, Kei Yura, Honami Teranishi, Noriko Kiyasu, Ayumi Tominaga, Haruka Kadoma, Ayaka Nakatsuka, Tomoko Kunichika, Chikashi Obuse, Shou Waga^*

^*この研究の対応する著者

研究成果: Article › 査読

69 被引用数 (Scopus)

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Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

本文言語	English
ページ（範囲）	30161-30171
ページ数	11
ジャーナル	Journal of Biological Chemistry
巻	288
号	42
DOI	https://doi.org/10.1074/jbc.M113.492504
出版ステータス	Published - 2013 10月 18
外部発表	はい

ASJC Scopus subject areas

生化学
分子生物学
細胞生物学

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title = "Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA",

abstract = "Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.",

author = "Shoko Hoshina and Kei Yura and Honami Teranishi and Noriko Kiyasu and Ayumi Tominaga and Haruka Kadoma and Ayaka Nakatsuka and Tomoko Kunichika and Chikashi Obuse and Shou Waga",

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doi = "10.1074/jbc.M113.492504",

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T1 - Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

AU - Hoshina, Shoko

AU - Yura, Kei

AU - Teranishi, Honami

AU - Kiyasu, Noriko

AU - Tominaga, Ayumi

AU - Kadoma, Haruka

AU - Nakatsuka, Ayaka

AU - Kunichika, Tomoko

AU - Obuse, Chikashi

AU - Waga, Shou

PY - 2013/10/18

Y1 - 2013/10/18

N2 - Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

AB - Background: ORC binds to replication origins, but human ORC does not exhibit apparent sequence-specificity. Results: G-quadruplex (G4)-preferable RNA or single-stranded DNA competes for DNA binding of ORC. Conclusion: HumanORCbinds preferentially toRNAand single-strandedDNAthat form G4, and the certain domain in ORC1 is involved in this binding. Significance: This ability may correlate with the G4-formable motif in human replication origins.

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Human origin recognition complex binds preferentially to G-quadruplex-preferable RNA and single-stranded DNA

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