Hyper-running activity originating from the hypothalamus is blocked by GABA

Takashi Yokawa, Kunio Shiota, Michio Takahashi

研究成果: Article

18 引用 (Scopus)

抄録

Our previous study showed that injection of the hydrogel of a water-absorbent polymer (WAPGEL) into the ventromedial nucleus of the hypothalamus (VMH) induced stereotyped long-lasting running activity without association of any aggressive reactions, and suggested that swelling of the polymer at the site of injection affected the inhibitory neuron system, resulting in the expression of running activity. In the present study, we injected WAPGEL impregnated with different doses of GABA. By this treatment, the expression of running activity was inhibited in a dose-dependent manner. Contrarily, microinjection of a GABA-A receptor blocker, bicuculline methiodide (BM), released the running reaction in a dose-dependent manner with similar features to that induced by WAPGEL. It is suggested that the running-related neurons in the VMH are inhibited by GABA when the animals are at rest.

元の言語English
ページ(範囲)1261-1264
ページ数4
ジャーナルPhysiology and Behavior
47
発行部数6
DOI
出版物ステータスPublished - 1990
外部発表Yes

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gamma-Aminobutyric Acid
Hypothalamus
Polymers
Neurons
Injections
Hydrogel
Microinjections
GABA-A Receptors
Water
Therapeutics
bicuculline methiodide

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

これを引用

Hyper-running activity originating from the hypothalamus is blocked by GABA. / Yokawa, Takashi; Shiota, Kunio; Takahashi, Michio.

:: Physiology and Behavior, 巻 47, 番号 6, 1990, p. 1261-1264.

研究成果: Article

Yokawa, Takashi ; Shiota, Kunio ; Takahashi, Michio. / Hyper-running activity originating from the hypothalamus is blocked by GABA. :: Physiology and Behavior. 1990 ; 巻 47, 番号 6. pp. 1261-1264.
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