Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

Takayoshi Ubuka, Shogo Haraguchi, Yasuko Tobari, Misato Narihiro, Kei Ishikawa, Takanori Hayashi, Nobuhiro Harada, Kazuyoshi Tsutsui*

*この研究の対応する著者

    研究成果: Article査読

    92 被引用数 (Scopus)

    抄録

    Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion and socio-sexual behaviours. Oestrogen (neuroestrogen) synthesized in the brain from androgen by aromatase regulates male socio-sexual behaviours. Here we show that GnIH directly activates aromatase and increases neuroestrogen synthesis in the preoptic area (POA) and inhibits socio-sexual behaviours of male quail. Aromatase activity and neuroestrogen concentration in the POA are low in the morning when the birds are active, but neuroestrogen synthesis gradually increases until the evening when the birds become inactive. Centrally administered GnIH in the morning increases neuroestrogen synthesis in the POA and decreases socio-sexual behaviours. Centrally administered 17β-oestradiol at higher doses also inhibits socio-sexual behaviours in the morning. These results suggest that GnIH inhibits male socio-sexual behaviours by increasing neuroestrogen synthesis beyond its optimum concentration for the expression of socio-sexual behaviours. This is the first demonstration of any hypothalamic neuropeptide that directly regulates neuroestrogen synthesis.

    本文言語English
    論文番号3061
    ジャーナルNature Communications
    5
    DOI
    出版ステータスPublished - 2014 1月 16

    ASJC Scopus subject areas

    • 生化学、遺伝学、分子生物学(全般)
    • 化学 (全般)
    • 物理学および天文学(全般)

    フィンガープリント

    「Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル