Identification and characterization of skin biomolecules for drug targeting and monitoring by vibrational spectroscopy

Natalja Skrebova Eikje, Katsuo Aizawa, Takayuki Sota, Yukihiro Ozaki, Seiji Arase

    研究成果: Article査読

    抄録

    The article discusses the application of vibrational spectroscopy techniques for in vivo identification and characterization of glucose biomolecules monitored in the skin of healthy, prediabetes and diabetes subjects; for molecular characterization of water and proteins in in vivo monitored patch tested inflamed skin of the patients with contact dermatitis; for description of nucleic acids and proteins at the molecular level with progression to malignancy in skin cancerous lesions. The results of the studies show new possibilities to assess activity levels of glucose metabolism in the skin tissue of healthy, prediabetes and diabetes subjects; activity and severity of inflammation; activity of the processes of carcinogenesis with regard to benign, premalignant and malignant transformation. Based on our findings, we suggest that vibrational spectroscopy might be a rapid screening tool with sufficient sensitivity and specificity to identify and characterize skin biomolecules in described diseases for drug targeting and monitoring by the pharmacological community.

    本文言語English
    ページ(範囲)38-48
    ページ数11
    ジャーナルThe open medicinal chemistry journal
    2
    DOI
    出版ステータスPublished - 2008 5 8

    ASJC Scopus subject areas

    • 分子医療
    • 薬理学
    • 薬科学
    • 創薬

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