Identification, biosynthesis, and function of 7α-hydroxypregnenolone, a new key neurosteroid controlling locomotor activity, in nonmammalian vertebrates

Kazuyoshi Tsutsui*, Shogo Haraguchi, Kazuhiko Inoue, Hitomi Miyabara, Saori Suzuki, Yuki Ogura, Teppei Koyama, Masahiro Matsunaga, Hubert Vaudry

*この研究の対応する著者

    研究成果: Conference contribution

    16 被引用数 (Scopus)

    抄録

    It is now clearly established that steroids can be synthesized de novo by the brain and the peripheral nervous systems. Such steroids are called neurosteroids, and de novo neurosteroidogenesis from cholesterol is a conserved property of vertebrate brains. Our studies over the past decade have demonstrated that the brain expresses several kinds of steroidogenic enzymes and produces a variety of neurosteroids in submammalian species. However, the biosynthetic pathway of neurosteroids in nonmammalian vertebrates as well as in mammals may be still incompletely mapped out. We recently found that the brain of newts and quail actively produces 7α-hydroxypregnenolone, a novel bioactive neurosteroid, from pregnenolone. Interestingly, 7α- hydroxypregnenolone stimulates locomotor activity by means of the dopaminergic system. Subsequently, we demonstrated that melatonin regulates synthesis of 7α-hydroxypregnenolone, a key factor for induction of locomotor activity, thus inducing diurnal locomotor changes.

    本文言語English
    ホスト出版物のタイトルAnnals of the New York Academy of Sciences
    ページ308-315
    ページ数8
    1163
    DOI
    出版ステータスPublished - 2009 4

    出版物シリーズ

    名前Annals of the New York Academy of Sciences
    1163
    ISSN(印刷版)00778923
    ISSN(電子版)17496632

    ASJC Scopus subject areas

    • 生化学、遺伝学、分子生物学(全般)

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