Identification of large ancient duplications associated with human gene deserts

Takehiko Itoh, Atsushi Toyoda, Todd D. Taylor, Yoshiyuki Sakaki, Masahira Hattori

研究成果: Article

4 引用 (Scopus)

抜粋

We identified 15 regions of >1 Mb in the human genome composed of large ancient local duplications corresponding to gene deserts. We detected these intrachromosomal duplications in mouse and dog but not in chicken; they present as patches of similarity as low as 60%. These findings suggest that some human gene deserts originated from duplications of segments lacking genes in a mammalian common ancestor.

元の言語English
ページ(範囲)1041-1043
ページ数3
ジャーナルNature Genetics
37
発行部数10
DOI
出版物ステータスPublished - 2005 10
外部発表Yes

    フィンガープリント

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

これを引用

Itoh, T., Toyoda, A., Taylor, T. D., Sakaki, Y., & Hattori, M. (2005). Identification of large ancient duplications associated with human gene deserts. Nature Genetics, 37(10), 1041-1043. https://doi.org/10.1038/ng1648